LL-K12-18 is a two-site molecular glue that enhances interaction between CDK12 and DDB1, stabilizing the complex and promoting selective degradation of cyclin K with an EC50 of 0.37 nM. It exhibits potent transcriptional repression and antiproliferative effects in tumor models, making it a valuable chemical tool for investigating transcriptional regulation and targeted protein degradation in cancer research.
Reinheit:
99.77%
Target-Kategorie:
CDK|||PROTACs
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
