LY3526318 is an orally active, selective TRPA1 antagonist with an IC50 of 5-6 µM. It blocks the TRPA1 channel, inhibiting pain signal transduction mediated by this channel and demonstrating analgesic activity. LY3526318 is primarily utilized in research related to chronic pain, such as diabetic peripheral neuropathic pain, chronic lower back pain, and osteoarthritis-induced pain.
Molekulargewicht:
556.46
CAS Nummer:
[1889218-34-1]
Formel:
C23H19F3N10O4
Target-Kategorie:
TRP/TRPV Channel
T210559
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