dA-NHbenzylOCF3 is a DNA-targeting radiosensitizer that enhances tumor cell sensitivity to X-rays via the dissociative electron attachment (DEA) mechanism. It exhibits low toxicity to normal cells and primarily localizes in the cytoplasm and nucleus after cellular entry. The compound induces radiosensitization by causing cell cycle arrest at the G2/M phase, which is sensitive to radiation. dA-NHbenzylOCF3 is applicable in research on radiosensitization for malignant tumors such as prostate and breast cancer.
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