FC-14367 is a PROTAC degrader targeting the HIV-1Nef protein. It forms a ternary complex by binding Nef with CereblonE3 ubiquitin ligase, inducing ubiquitination of Nef and its subsequent proteasomal degradation. This restores cell surface CD4 and MHC-I expression, inhibiting HIV-1 replication. FC-14367 is useful for research on HIV infection and AIDS.
Molekulargewicht:
740.18
CAS Nummer:
[3066893-65-7]
Formel:
C38H35ClFN7O6
Target-Kategorie:
HIV Protease|||PROTACs
T210691
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