ATR/PARP1-IN-1 is a dual inhibitor of ATR/PARP1, exhibiting an IC50 of 17.3 nM for ATR and 0.38 nM for PARP1. It effectively reduces cell viability, induces apoptosis, and causes DNA damage. In triple-negative breast cancer (TNBC) models, ATR/PARP1-IN-1 significantly inhibits colony formation, migration, and invasion. Additionally, in MDA-MB-468 xenograft mouse models, it suppresses tumor growth without significant changes in body weight.
Target-Kategorie:
Apoptosis|||PARP|||ATM/ATR
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