AZ12943203 (Compound 13e) is a PET radioligand targeting GSK-3, with a Kd of 2.94 nM. It demonstrates significant inhibitory potency against GSK-3beta (IC50: 4.44 nM) and specifically binds to GSK-3-rich regions in the rodent brain. AZ12943203 is applicable for imaging neurodegenerative diseases, particularly Alzheimers disease.
Target-Kategorie:
Others|||GSK-3
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