CDK4-IN-3 (Compound 389) is a highly selective irreversible inhibitor of cyclin-dependent kinase 4 (CDK4) with an IC50 of 25 nM and exhibits more than 10-fold selectivity over CDK6. It arrests the cell cycle at the G1 phase and induces apoptosis in tumor cells. CDK4-IN-3 holds potential for research in solid tumors such as breast and lung cancer.
Molekulargewicht:
481.56
CAS Nummer:
[3002399-75-6]
Formel:
C26H32FN5O3
Target-Kategorie:
Apoptosis|||CDK
T210727
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