AMG 7905 TFA is a transient receptor potential vanilloid type 1 (TRPV1) antagonist that induces hypothermia. It enhances the activation of TRPV1 channels by protons, leading to the reflexive inhibition of thermogenesis and vasoconstriction in the tail skin, while effectively blocking capsaicin-induced channel activation.
Target-Kategorie:
TRP/TRPV Channel
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