DW34 is an orally bioactive pan-BRD4-D1-biased inhibitor that also exhibits BRD4-D2 activity. It demonstrates a low nanomolar inhibitory effect comparable to I-BET151 (EC50 value of 0.16 µM), with an EC50 value of 0.14 µM. DW34 significantly alleviates lipopolysaccharide (LPS)-induced liver inflammation and acetaminophen (APAP)-induced toxicity by reducing chemokine expression and cell necrosis.
Molekulargewicht:
434.58
CAS Nummer:
[2758171-54-7]
Formel:
C25H34N6O
Target-Kategorie:
Necroptosis|||Epigenetic Reader Domain
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