NF-kappaBdegrader 1 (Compound MD-1) is an NF-kappaB1p105 subunit degrader. It exhibits anti-inflammatory properties, with an IC50 of 2.02 µM for inhibiting TNF-alpha and 5.40 µM for inhibiting NO. NF-kappaBdegrader 1 induces p105 degradation via the Cullin-RING ligase (CRL) SCFBTCP, thereby inhibiting NF-kappaB transcriptional activity. This compound shows potential for research in inflammation-related diseases.
Target-Kategorie:
NF-kappaB
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