Skp2-IN-4 is an Skp2 inhibitor with an IC50 of 0.38 µM for Skp2-Cks1 binding. It enhances antitumor activity by targeting Skp2, inhibiting tumor proliferation, and inducing S phase cell arrest. Skp2-IN-4 also significantly boosts chemosensitivity to Cisplatin in the NCl-H1299 xenograft mouse model by inhibiting tumor cell stemness, presenting potential for lung and esophageal cancer research.
Target-Kategorie:
E1/E2/E3 Enzyme
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