JNK-IN-23 (Compound K12) is an inhibitor of JNK. It effectively inhibits the proliferation of MDA-MB-231 cells with a GIC50 of 30 nM. In vivo, JNK-IN-23 blocks metastatic growth of triple-negative breast cancer (TNBC). Additionally, it suppresses the growth of lung metastases by dual targeting of glutaminase-1 (GLS) and the pyruvate dehydrogenase complex (PDHC).
Molekulargewicht:
382.5
CAS Nummer:
[1007786-48-2]
Formel:
C19H18N4OS2
Target-Kategorie:
JNK
T210950
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