TAU-IN-3 (Compound 2) is an orally active TAU inhibitor that suppresses the expression of the MAPT exon 10 DDPAC mutant gene in HeLa cells (IC50: 0.6 µM). It reduces the 4R/3R MAPT mRNA ratio in HeLa cells transfected with WT or DDPAC minigenes. TAU-IN-3 inhibits the insertion of endogenous MAPT exon 10 and the production of 4R tau protein. It modulates tau splicing in htau mice and improves associated behavioral phenotypes. TAU-IN-3 is useful for researching neurodegenerative diseases.
Molekulargewicht:
434.53
CAS Nummer:
[3063511-09-8]
Formel:
C24H30N6O2
Target-Kategorie:
Microtubule Associated
T211092
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