EGFR-IN-163 (Compound 13) is a competitive inhibitor of the epidermal growth factor receptor (EGFR) with an IC50 of 0.079 µM and selective inhibition on HER-2. It induces apoptosis in tumor cells and causes cell cycle arrest at the G2/M phase. EGFR-IN-163 shows promise for investigating estrogen receptor-positive (ER+) breast cancer.
Target-Kategorie:
EGFR|||Apoptosis
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