NMT-IN-8 (Compound Ex.129) is an orally active and highly selective N-myristoyltransferase (NMT) inhibitor with an IC50 value of less than 10 nM. It binds to the peptide binding pocket of NMT, blocking the enzyme-catalyzed protein N-myristoylation, thereby disrupting key pathways such as protein transport, signal transduction, and viral replication. NMT-IN-8 shows promise for research in oncology (including MYC-dependent cancers and B-cell lymphoma) and infectious diseases (such as malaria, HIV, and rhinovirus infections).
Molekulargewicht:
468.98
CAS Nummer:
[2765258-26-0]
Formel:
C23H29ClN8O
Target-Kategorie:
Others
T211166
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