GT-02216 is capable of binding allosterically to GCase, thereby enhancing its function. In primary human fibroblasts, it increases GCase activity and decreases Tau accumulation in mutant GBA1 fibroblasts. Additionally, GT-02216 offers protection to hippocampal primary neurons exposed to Tau oligomer in a rat model.
Molekulargewicht:
389.45
CAS Nummer:
[2648407-76-3]
Formel:
C22H23N5O2
Target-Kategorie:
glycosidase
T211168
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