P2Y14R antagonist 5 (Compound A) is a novel P2Y14R antagonist with a benzisoxazole-based structure, exhibiting an IC50 of 23.60 nM and a KD of 7.26 µM. This compound can reduce levels of pro-inflammatory factors (IL-1beta, IL-6, TNF-alpha) and myeloperoxidase (MPO). It demonstrates anti-inflammatory activity in a mouse model of LPS-induced acute lung injury.
Target-Kategorie:
P2Y Receptor
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