TK-684 is a potent and selective allosteric inhibitor of SHP2, with IC50 values of 2.1 nM for SHP2WT and greater than 1000 nM for SHP2PTP. It inhibits cell proliferation and induces apoptosis (apoptosis). Additionally, TK-684 reduces the protein expression of p-AKT and p-ERK.
Target-Kategorie:
Apoptosis|||Phosphatase
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