Mtb-IN-12 (Compound 5m) is a dual-target inhibitor that acts on the Mycobacterium tuberculosis enzymes CYP125 with a dissociation constant (KD) of 40 nM and an inhibition constant (KI) of 0.1 µM, and CYP142 with a KD of 160 nM and a KI of 0.05 µM. It effectively inhibits both drug-sensitive and multidrug-resistant strains of the tuberculosis bacterium, with low toxicity to macrophages, making it useful for studying anti-tuberculosis treatments.
Target-Kategorie:
Antibacterial|||Cytochromes P450
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