MI891 is a highly selective PXR antagonist (IC50= 3.76 µM, Kd= 1.7 µM) and inverse agonist (IC50= 6.1 µM). It selectively disrupts the interaction between PXR and its coactivator SRC1. MI891 effectively inhibits Rifampicin-induced PXR activation and can be utilized in research on metabolic and other diseases.
Molekulargewicht:
499.3
CAS Nummer:
[2530027-77-9]
Formel:
C23H14Cl2F2N6O
Target-Kategorie:
Others|||Cytochromes P450
T211422
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