TNKS-2-IN-3, CAS [[2580941-64-4]] Preis auf Anfrage

Produktübersicht

• Artikelname: TNKS-2-IN-3, CAS [[2580941-64-4]] Preis auf Anfrage
• Artikelnummer: TGM-T211575
• Hersteller Artikelnummer: T211575
• Alternativnummer: TGM-T211575-10MG,TGM-T211575-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

TNKS-2-IN-3 (Compound 5) is a selective and competitive inhibitor of Tankyrase 2 (TNKS2), with an IC50 value of 0.3 nM. It exhibits over 20-fold selectivity for TNKS2 compared to TNKS1 and more than 100-fold selectivity over PARP1/2. By inhibiting TNKS2-mediated ADP ribosylation, TNKS-2-IN-3 stabilizes axin and suppresses the Wnt/beta-catenin pathway, demonstrating antiproliferative activity in colorectal cancer cells. TNKS-2-IN-3 holds potential for research in solid tumors with aberrant Wnt pathway activation, such as colorectal cancer.

Produkteigenschaften

• Molekulargewicht: 494.63
• CAS Nummer: [2580941-64-4]
• Formel: C24H26N6O2S2
• Target-Kategorie: PARP

Bilder

T211575