STAT3-IN-44 is a potent STAT3 inhibitor with IC50 values of 1.84 µM (C6 cells) and 4.81 µM (A549 cells). It inhibits the phosphorylation of STAT3, downregulates Bcl-2 expression, and upregulates Caspase-3 expression, thereby promoting late-stage apoptosis. STAT3-IN-44 effectively suppresses tumor cell proliferation and migration and is applicable in research on cancers such as glioma and lung cancer.
Target-Kategorie:
Apoptosis|||Caspase|||Bcl-2 Family|||STAT
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