Jun6504 is an inhibitor of enterovirus (enterovirus) 2C protein. It exhibits potent broad-spectrum antiviral activity against various strains of EV-D68 (EC50= 250 nM), EV-A71 (EC50= 502.4 nM), and CVB3 (EC50= 1049 nM). In a neonatal mouse model infected with EV-D68, Jun6504 improves paralysis scores and promotes weight gain. It reduces viral titers in the spinal cord and infected quadriceps muscle. Jun6504 is useful for researching antivirals against EV-D68.
Target-Kategorie:
Virus Protease
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