WHN-11, an amino-Artemisinin derivative, exhibits anticancer activity against various cancer cell lines. It depletes cellular ATP, activates autophagy, and triggers apoptosis. WHN-11 disrupts cellular protein homeostasis pathways, inducing mitochondrial fission and dysfunction. Its anticancer effects are not associated with the generation of reactive oxygen species. WHN-11 is applicable for studies on triple-negative breast cancer (TNBC).
Target-Kategorie:
Apoptosis|||Autophagy
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