CHI3L1-IN-3 is a CHI3L1 inhibitor that binds to CHI3L1 with dissociation constants (Kd) of 13.76 µM and 13.5 µM as measured by MST and SPR assays, respectively. It demonstrates an extended plasma half-life and microsomal stability, along with a low intrinsic clearance rate. In three-dimensional multicellular glioblastoma (GBM) spheroid models, CHI3L1-IN-3 induces dose-dependent cytotoxicity, reduces spheroid mass, and inhibits cell migration. This compound is valuable for glioblastoma research.
Target-Kategorie:
glycosidase
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