ATF3-IN-1 is an inhibitor of both ferroptosis and ATF3. It mitigates oxidative stress and ferroptosis through the ATF3/SLC7A11/GPX4 pathway, offering protection against ischemic stroke. ATF3-IN-1 can reduce ischemia/reperfusion (I/R) injury and enhance neuron survival, demonstrating neuroprotective effects, making it valuable for ischemic stroke research.