Anti-MRSA agent 32 (Compound 26) is an orally active selective activator of the Staphylococcus aureus ClpP protease (SaClpP) with an EC50 of 0.98 µM. By activating the SaClpP protease, it causes the abnormal degradation of bacterial proteins and inhibits the proliferation of Staphylococcus aureus. In a mouse skin infection model, Anti-MRSA agent 32 promotes wound healing. This compound holds potential for research in methicillin-resistant Staphylococcus aureus (MRSA) and other infectious diseases.
Target-Kategorie:
Antibacterial
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