D1/D5 Receptor agonist-1 is an orally active D1/D5 receptor agonist with the ability to cross the blood-brain barrier. It demonstrates significant efficacy in the cAMP pathway and beta-arrestin recruitment, with EC50 values of 3.7 nM for D1R cAMP, 91 nM for D1R beta-arrestin, and 129 nM for D1R internalization, and a Ki value of 111 nM for D1R binding affinity. In rats, D1/D5 Receptor agonist-1 inhibits beta-arrestin signaling involved in L-DOPA-induced dyskinesia. This compound is applicable in Parkinsons disease research.
Target-Kategorie:
Arrestin|||Dopamine Receptor
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