EGFRT790M/VEGFR-2-IN-1 (Compound 6) is a dual inhibitor targeting the EGFRT790M mutant (IC50=0.26 µM) and VEGFR-2 (IC50=0.95 µM). It effectively blocks tumor cell proliferation and angiogenesis signaling pathways. This compound exhibits potent cytotoxicity against various cancer cell lines (HCT116, MCF-7, HepG2, A549, IC50=5.35-9.90 µM) and holds potential for research in non-small cell lung cancer and solid tumors.
Target-Kategorie:
VEGFR|||EGFR
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