ER-Tracker Red (solution) dye is a derivative of BODIPY dyes conjugated to Glibenclamide, exhibiting high selectivity for binding to the endoplasmic reticulum without toxicity to cells at low concentrations. This environmentally sensitive probe retains some fluorescence even after formaldehyde treatment and is characterized by high fluorescence lifetime and good extinction coefficients. Glibenclamide acts as an ATP-sensitive K+ channel blocker (Kir6, KATP) and CFTR Cl- channel blocker, binding within the endoplasmic reticulum. Note that ER-Tracker is not suitable for staining fixed cells. Ex/Em=587/615 nm.
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