TPP-IOA is a cytochrome c peroxidase inhibitor. It prevents apoptosis by blocking cardiolipin oxidation and the release of cytochrome c into the cytosol. TPP-IOA interferes with oxidative phosphorylation in isolated mitochondria. It inhibits cell death of SH-SY5Y cells in glucose medium but is ineffective in galactose medium. Additionally, TPP-IOA induces mitochondrial depolarization and network fragmentation, and it reduces radiation-induced mortality in mice.
Molekulargewicht:
731.78
CAS Nummer:
[1423018-61-4]
Formel:
C42H56BrN2O2P
Target-Kategorie:
Apoptosis|||OXPHOS|||Mitochondrial Metabolism
T212163
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