RBM1-151 is a 1-deoxy derivative and vinyl analog of RBM14-C12, serving as a fluorescent substrate for amidases (Ex/Em = 355/460 nm). It is hydrolyzed by acidic ceramidase (AC) (appKm = 7.0 µM, appVmax = 99.3 nM/min), N-acylethanolamine hydrolyzing acid amidase (appKm = 0.73 µM, appVmax = 0.24 nM/min), and fatty acid amide hydrolase (FAAH) (appKm = 3.6 µM, appVmax = 7.6 nM/min), but is not hydrolyzed by other ceramidases. RBM1-151 is useful for studying the basic biology of lipid amidase functions and for potential diagnostic/prognostic assessments in disorders involving AC, NAAA, or FAAH dysregulation, such as Farber disease and cancer.
Molekulargewicht:
471.63
CAS Nummer:
[3077081-47-8]
Formel:
C28H41NO5
Target-Kategorie:
Others
T212199
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