Enpp-1/3-IN-1 (Compound 5j) serves as an inhibitor for ENPP1 and ENPP3, with IC50 values of 0.59 µM for h-ENPP1 and 0.62 µM for h-ENPP3, respectively. This compound also inhibits e5'NT (CD73) and TNAP, exhibiting IC50 values of 0.89 µM for h-e5'NT, 5.12 µM for r-e5'NT, and 1.68 µM for h-TNAP. Enpp-1/3-IN-1 is applicable in cancer research.
Target-Kategorie:
Phosphatase|||CD73|||PDE
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