VVD-849 is a RAS ligand that covalently binds to cysteine at position 242 within the RAS binding domain of PI3Kp110alpha, enhancing RAS/PI3K interaction. It partially inhibits pAKT(S473) in tumors overexpressing HER2. VVD-849 is applicable in cancer research, including studies on breast cancer.
Molekulargewicht:
636.15
CAS Nummer:
[3055321-14-4]
Formel:
C29H31ClFN3O6S2
Target-Kategorie:
PI3K|||Ras
T212213
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