TRK-IN-32 is a potent TRK inhibitor. It significantly suppresses TRKWT, TRKG595R, and TRKG667C with IC50 values of 0.08 nM, 2.14 nM, and 0.68 nM, respectively. Additionally, TRK-IN-32 exhibits antiproliferative activity against various Ba/F3 cell lines transformed by wild-type, xDFG mutant, solvent front, and gatekeeper mutant TRK fusion proteins. It also induces apoptosis in Ba/F3-TRKAWT and Ba/F3-TRKAG667C cells. TRK-IN-32 is applicable in research on various cancers, including thyroid cancer and secretory breast cancer.
Molekulargewicht:
363.39
CAS Nummer:
[3044124-79-7]
Formel:
C19H18FN7
Target-Kategorie:
Apoptosis|||Trk receptor
T212244
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