MAO-B-IN-46 (Compound 16) is a selective human MAO-B inhibitor with an IC50 of 26.8 nM, while showing weaker activity against hMAO-A (IC50: 7.2054 µM). This compound, also referred to as MAO-B-IN-46 (Compound 8), acts as an alpha-amylase inhibitor with an IC50 of 19.46 µM. It demonstrates certain neuroprotective properties and exhibits no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS radicals, with IC50 values of 17.86 and 17.71 µM, respectively. MAO-B-IN-46 is applicable in research on neurodegenerative diseases like Parkinsons, diabetes, and conditions related to oxidative stress.
Molekulargewicht:
256.68
CAS Nummer:
[27052-20-6]
Formel:
C15H9ClO2
Target-Kategorie:
Amylase|||Monoamine Oxidase
T212299
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