PI3Kdelta-IN-25 is an orally active and selective PI3Kdelta inhibitor with an IC50 of 2.1 nM. It exhibits IC50 values of 272, 285, and 1171 nM for PI3Kalpha, PI3Kgamma, and PI3Kbeta, respectively. In B16F10 cells, PI3Kdelta-IN-25 inhibits the phosphorylation of AKTSer473, suppresses Treg cell proliferation, and downregulates the expression of PD-L1. In mouse models of B16F10 melanoma and Lewis lung cancer, PI3Kdelta-IN-25 demonstrates anticancer activity by reducing tumor-infiltrating Treg cells and enhancing immune responses. This compound is applicable for research on cancers such as melanoma and lung cancer.
Target-Kategorie:
PD-1/PD-L1|||Interleukin|||Akt|||Integrin|||PI3K
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