MAO-B-IN-48 is a selective inhibitor of MAO-B with an IC50 of 0.09 µM and Ki of 0.02 µM. It also demonstrates inhibitory activity against hBChE (IC50= 1.10 µM, Ki= 0.43 µM) and AChE (IC50= 0.56 µM, Ki= 0.14 µM). MAO-B-IN-48 disrupts the self-induced aggregation of toxic beta-amyloid peptides and exhibits antioxidant properties, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. This compound is applicable in Alzheimers disease (AD) research.
