P-gp-IN-31 is an inhibitor of P-glycoprotein (P-gp) with IC50 values of 0.42 µM for KB cells and 0.43 µM for MDR KBvin cells. This compound effectively overcomes P-gp mediated drug efflux, exhibiting collateral sensitivity through P-gp downregulation. P-gp-IN-31 inhibits cell proliferation, induces apoptosis (apoptosis), and arrests the cell cycle in the G2/M phase. It is applicable in cancer research, particularly for multidrug-resistant (MDR) malignancies.
Target-Kategorie:
P-gp|||Apoptosis
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