SBP-1750 is a potent, orally active autophagy inhibitor with a dual mechanism of action. It functions as a kinase inhibitor, strongly suppressing ULK1 (IC50 = 8 nM) and ULK2 (IC50 = 50 nM) activity, while simultaneously inducing the degradation of ATG13 (EC50 = 114 nM). This dual-targeting approach effectively blocks autophagic flux and induces cell death, exhibiting significant efficacy particularly against KRAS-mutant cancers such as pancreatic and lung cancers.
Molekulargewicht:
443.88
Reinheit:
99.59%
CAS Nummer:
[1884219-70-8]
Formel:
C21H22ClN5O4
Target-Kategorie:
ATG|||Autophagy
T212604
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