Losmapimod hydrochloride (GW856553X) is an orally active, potent, and highly selective p38 alpha/beta MAPK inhibitor (IC50 = 0.8 nM). It greatly reduces the release of pro-inflammatory cytokines, including TNF-alpha and IL-6, by blocking inflammatory signaling cascades, showing remarkable efficacy in COPD and severe cardiovascular inflammation models.
Molekulargewicht:
419.92
Reinheit:
99.98%
CAS Nummer:
[1246654-84-1]
Formel:
C22H27ClFN3O2
Target-Kategorie:
p38 MAPK
T212725
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