Dichloro(bipyridine)platinum is a potent platinum-based antitumor complex and a structural analogue of cisplatin. The incorporation of the bipyridine ligand enhances its lipophilicity and planar stacking ability. The compound interacts with DNA through covalent binding or intercalation, forming cis-Pt-DNA adducts that disrupt DNA replication and transcription. Research indicates that such complexes effectively activate pro-apoptotic signaling pathways and exhibit significant growth inhibition across various cancer cell lines, including those resistant to cisplatin. It serves as a foundational scaffold for developing next-generation metallodrugs in oncology.
Molekulargewicht:
422.17
Reinheit:
97.02%
CAS Nummer:
[13965-31-6]
Formel:
C10H8Cl2N2Pt
Target-Kategorie:
DNA
T212775
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