FGFR-IN-23 (Compound 9p) is a covalent pan-FGFR inhibitor with IC50 values of 14 nM, 4.2 nM, 5 nM, and 220 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. It also effectively inhibits gatekeeper gene mutants such as FGFR1V561M and FGFR3V555M. FGFR-IN-23 suppresses FGFR-mediated signaling activation and induces apoptosis. In RT112 xenograft mouse models, FGFR-IN-23 demonstrates significant antitumor efficacy. It is applicable for research in cancer and its drug resistance.
Target-Kategorie:
p38 MAPK|||Apoptosis|||Akt|||ERK|||FGFR
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