Troponin-IN-1 is a troponin inhibitor that protects H9c2 cardiomyocytes from OGD/R injury by reducing LDH leakage, pyroptosis, and reactive oxygen species (ROS) accumulation. In LPS-induced RAW264.7 cells, it suppresses NO production and the release of IL-1beta, TNF-alpha, and IL-18. Troponin-IN-1 functions through the caspase-1/GSDMD/IL-18 signaling pathway and reduces myocardial infarction size in a LAD-induced myocardial ischemia/reperfusion (MI/R) male rat model. It is a valuable compound for studying myocardial ischemia/reperfusion injury.
Target-Kategorie:
Caspase|||ROS|||Pyroptosis|||Interleukin
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