SMU-V18 is a vesicular stomatitis virus (VSV) inhibitor with an EC50 of 6.2 µM. It suppresses VSV-GFP fluorescence intensity, viral mRNA/protein expression, and progeny virus replication. SMU-V18 interferes with the early stages of viral infection and is effective against wild-type VSV (VSV-WT). Additionally, it suppresses VSV-GFP in mouse tissues and extends survival in mice. SMU-V18 is useful for studying vesicular stomatitis virus (VSV) infections.
Target-Kategorie:
Influenza Virus
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