MU876 (Compound 32) is an MUS81 inhibitor with an IC50 of 0.5 µM. It effectively inhibits MUS81-dependent homologous recombination (HR) and break-induced replication (BIR) pathways. MU876 enhances the sensitivity of cancer cells to DNA-damaging agents like Cisplatin by impairing their ability to repair DNA damage. This compound is applicable in cancer chemotherapy research.
Molekulargewicht:
438.45
CAS Nummer:
[1208829-24-6]
Formel:
C24H18N6O3
Target-Kategorie:
Endonuclease
T213240
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