Prostratin (12-Deoxyphorbol-13-acetate) is an orally active protein kinase C (PKC) activator with a Ki value of 12.5 nM.As an NF-kappaB activator, Prostratin activates HIV gene expression in T cells.Prostratin inhibits the growth of acute myeloid leukemia (AML) cell lines and enhances cytarabine-induced AML cell differentiation. In addition, Prostratin induced KRAS phosphorylation and inhibited the growth of KRAS-mutated tumors.
Molekulargewicht:
390.47
CAS Nummer:
[60857-08-1]
Formel:
C22H30O6
Target-Kategorie:
PKC|||Kras|||HIV Protease|||Ras|||NF-kappaB
T21441
T21441
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