SKF-96365 hydrochloride, CAS [[130495-35-1]]

Produktübersicht

• Artikelname: SKF-96365 hydrochloride, CAS [[130495-35-1]]
• Artikelnummer: TGM-T2170
• Hersteller Artikelnummer: T2170
• Alternativnummer: TGM-T2170-1MLX10MM(INDMSO),TGM-T2170-5MG,TGM-T2170-10MG,TGM-T2170-25MG,TGM-T2170-50MG,TGM-T2170-100MG,TGM-T2170-200MG,TGM-T2170-500MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: SKF96365

Produktbeschreibung

SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 hydrochloride treatment inhibited the calcium/calmodulin-dependent protein kinase IIgamma (CaMKIIgamma)/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKIIgamma or AKT abolished the effects of SKF-96365 on Y cells, suggesting a critical role of the CaMKIIgamma/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 hydrochloride inhibited hERG current in a concentration-dependent manner.

Produkteigenschaften

• Molekulargewicht: 402.91
• Reinheit: 99.47%
• CAS Nummer: [130495-35-1]
• Formel: C22H27ClN2O3
• Target-Kategorie: Apoptosis|||Calcium Channel|||TRP/TRPV Channel|||Autophagy|||Potassium Channel

Bilder

T2170