mmu-miR-449a-5p antagomir is a chemically modified complementary single strand of mature miRNA, with methoxy modifications across the entire chain. It features two and four thiol modifications at the 5 and 3 ends, respectively, and is linked to a high-affinity cholesterol modification at the 3 end. The miRNA antagomir inhibits the function of miRNA by specifically binding to the mature miRNA, thereby preventing its complementary pairing with target genes. Compared to a miRNA inhibitor, the miRNA antagomir demonstrates greater stability and inhibitory efficiency in animal studies, and it more readily penetrates cell membranes and tissue gaps to accumulate in target cells.
Target-Kategorie:
MicroRNA
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