LT175, a dual PPARalpha/gamma ligand, demonstrates potent insulin-sensitizing effects with reduced adipogenic properties. This orally active partial agonist targets PPARgamma with EC50 values of 0.22 µm for hPPARalpha, 0.26 µm for mPPARalpha, and 0.48 µm for hPPARgamma. LT175 specifically interacts with PPARgamma, influencing the recruitment of coregulators, such as the cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1), within a hydrophobic region known as the diphenyl pocket [1].
Molekulargewicht:
318.37
CAS Nummer:
[862901-87-9]
Formel:
C21H18O3
Target-Kategorie:
Others|||PPAR
T21812
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